Relationship out of Maternal Folate and you may Supplement Ba dozen in early Maternity That have Gestational All forms of diabetes Mellitus: A possible Cohort Studies

Relationship out of Maternal Folate and you may Supplement Ba dozen in early Maternity That have Gestational All forms of diabetes Mellitus: A possible Cohort Studies

Organization from Maternal Folate and you may Supplement B12 in early Maternity Which have Gestational Diabetes Mellitus: A potential Cohort Analysis

Xiaotian Chen, Yi Zhang, Hongyan Chen, Yuan Jiang, Yin Wang, Dingmei Wang, Mengru Li, Yalan Dou, Xupeng Sun, Guoying Huang, Weili Yan; Association of Maternal Folate and Vitamin B12 in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study. Diabetes Care ; 44 (1): 217–223.

The data of this study were from a subcohort within the Shanghai Preconception Cohort Study. We included pregnancies with red blood cell (RBC) folate and vitamin B12 measurements at recruitment (between 9 and 13 gestational weeks) and those with three samples available for glucose measurements under an oral glucose tolerance test. GDM was diagnosed between 24 and 28 weeks’ gestation. Odds ratio (OR) and 95% CI of having GDM was used to quantify the association.

A total of 1,058 pregnant women were included, and GDM occurred in 180 (%). RBC folate and vitamin B12 were significantly higher in pregnancies with GDM than those without GDM (P values were 0.045 and 0.002, respectively) and positively correlated with 1-h and 2-h serum glucose. Daily folic acid supplementation in early pregnancy increases the risk of GDM; OR (95% CI) was 1.73 (1.19–2.53) (P = 0.004)pared with RBC folate <400 ng/mL, pregnancies with RBC folate ?600 ng/mL were associated with ?1.60-fold higher odds of GDM; the adjusted OR (95% CI) was 1.58 (1.03–2.41) (P = 0.033). A significant trend of risk effect on GDM risk across categories of RBC folate was observed (Ptrend = 0.021). Vitamin B12 was significantly associated with GDM risk (OR 1.14 per 100 pg/mL; P = 0.002). No significant association of serum folate and percentile ratio of RBC folate/vitamin B12 with GDM was observed.

Higher maternal RBC folate and vitamin B12 levels in early pregnancy are significantly associated with GDM risk, while the balance of folate/vitamin B12 is not significantly associated with GDM.


Among the most typical maternity complications, gestational all forms of diabetes mellitus (GDM) impacts ?17% off pregnancies globally (1). Inside Asia, ?dos.nine mil expecting mothers experience this disorder (2). GDM provides long-label bad outcomes in mothers and girls and boys (3). Even with its severe challenge, the latest analysis off GDM isn’t performed until the late next or very early third trimester (4). Investigating convertible chance products in early maternity stage carry out more rather donate to the first prevention out of GDM.

Folate and vitamin B12, metabolically entwined during one-carbon metabolism, are both key nutrients in early pregnancy and involved in the DNA methylation and cell metabolism (5–7). Folic acid supplementation (FAS) of 0.4 mg/day is conventionally recommended for women of the childbearing age before and during the first trimester of pregnancy for the essential role of folate in the prevention of neural tube defects (NTDs) (8,9). The mandatory folic acid fortification aimed to alleviate micronutrient deficiencies has been implemented by >50 countries (10). Nevertheless, the relationship between folate and GDM risk with inconsistent findings has emerged as a field of interest. The Nurses’ Health Study II including 14,533 women has observed that FAS before pregnancy is associated with a lower risk of GDM (11); in contrast, another cohort study gave opposite conclusions that daily folic acid intake in early pregnancy increased the risk of GDM (12), reminding us that the association of folate with GDM is still equivocal.

Compared to solution folate, reddish bloodstream telephone (RBC) folate responds reduced to help you alterations in folate consumption and you may is short for the newest long-name folate condition, because erythrocytes has a beneficial 120-time life time and only gather folate throughout the erythropoiesis (13). Because solution folate are a sign of the latest folate consumption and you can are considerably impacted by FAS, these circumstances-manage studies are at the mercy of prejudice derived from diet folic acid (13). As such, examining the new relationship regarding RBC folate with GDM tend to be beneficial to elucidate the long-label visibility out of folate and you may GDM exposure. A good fifteen-season national cohort seen highest RBC folate is on the an enhanced danger of death certainly one of adults having all forms of diabetes (14). Xie ainsi que al. (15) discovered maternal RBC folate density into the 2nd trimester significantly when you look at the organization having an increased chance of GDM, which is diagnosed in the same period of pregnancy. If maternal RBC folate visibility at the beginning of pregnancy of frequency out-of GDM hasn’t been examined.

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